New research reveals that people who discontinue blockbuster weight-loss injections like semaglutide or tirzepatide can put back on lost weight much more quickly than those who stop conventional diet and exercise regimens.
Research printed in a major medical journal points out that while overweight people frequently drop a large proportion of their total mass while undergoing treatment, the weight is regained at an average rate of nearly a kilo each month upon discontinuation.
"Users purchasing such treatments need to be informed of the risk of rapid rebound weight gain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
That rate of recovery means a reversion to original weight within about 18 months.
Comparing Therapies
The research, which looked at dozens of trials involving thousands of patients, compared the outcomes of the injectable medications with conventional dieting.
Scientists emphasize that people who shed pounds through diet and exercise typically have a less rapid weight regain—perhaps 0.1 kg a month—after stopping.
Explaining the Quick Regain
Doctors believe the way of the jabs accounts for the heightened rebound.
GLP-1 drugs mimic a body's own chemical called GLP-1, which moderates appetite.
"Sustained high doses of the hormone levels several times higher than normal may cause the body to produce less of its endogenous hormone, and may also reduce sensitivity to its actions," said Dr. Adam Collins, a nutrition researcher.
"Discontinuation of this GLP-1 'fix' means appetite is uncontrolled, making overeating a significant risk."
An Ongoing Issue?
Medical guidelines recommend the injections for individuals with obesity-related health risks, alongside prescribed lifestyle changes.
A number of clinicians contend that, given the significant potential of relapse, the treatment should be considered long-term.
This opinion is echoed by pharmaceutical companies, who state that the findings "underscore the chronic nature of obesity," akin to managing conditions like diabetes.
Patient Testimonies
Individuals who have discontinued the jabs report a sudden return of appetite.
"It felt as if something activating and you become extremely hungry," recalled a patient.
This challenge is worsened if patients have not adopted lasting dietary or behavioural modifications during treatment.
Significant Use
Recent estimates suggest that millions of adults in the UK have used these injections in the past year, with demand being substantial.
- Adoption is more common among women than men.
- The middle-aged age group shows the highest usage rates.
- Many obtain the drugs through private prescriptions rather than the NHS.
In conclusion, experts caution that while the jabs are effective tools for weight loss, they are not a magic solution and long-term success hinges on ongoing behavioural management.
